Grey’s Anatomy season 22 out on OTT: The story continues from the Season 21 finale episode in which the hospital turned into an emergency situation as a massive explosion wreaked havoc.

Grey's Anatomy season 22 is now streaming on JioHotstar and OTTplay Premium
Last Updated: 07.39 PM, Oct 10, 2025
Grey’s Anatomy season 22 is finally out on OTT, and fans are back for a binge-watch ride as Ellen Pompeo’s long-running medical show returns on screen. ABC’s popular medical series has dropped episode 1 of Grey’s Anatomy 22, and it takes you to the previous season’s finale, when Grey Sloane Hospital turns into chaos with an explosion and medical emergency.
Grey’s Anatomy season 22 premiered the first episode on October 10. The story continues from the Season 21 finale episode in which the hospital turned into an emergency situation as a massive explosion wreaked havoc. You can watch Grey’s Anatomy season 22 on JioHotstar (accessible via OTTplay Premium).
Ellen Pompeo narrates the latest season in her attractive voice as she reveals the trust relationship between patients and their doctors. Grey’s Anatomy premiered on Friday with episode 1 titled “Only the Strong Survive.”
You can watch new episodes every week. Episode 2, titled “We Built This City,” is set to premiere on 17 October around 2-3 pm. This season is also expected to consist of 18 episodes like the previous season. Meanwhile, catch all the seasons on JioHotstar.
Watch the trailer here:
Grey’s Anatomy season 22 revolves around the events surrounding the catastrophic explosion in the hospital and will follow Grey Sloan’s staff saving their professional and personal lives. Ellen Pompeo returns as the titular character and also this season’s narrator as Dr. Meredith Grey.
Dr. Miranda Bailey (played by Chandra Wilson) and Dr. Richard Webber (James Pickens Jr.) are also back as the recurring main cast.
Also Read: Grey’s Anatomy returns for Season 20, check out teaser to know who’s answering the ‘medical calls’
The supporting ensemble includes Kevin McKidd as Owen Hunt, Caterina Scorsone as Amelia Shepherd, Jason George as Ben Warren, Alexis Floyd as Simone Griffith, Camilla Luddington as Jo Wilson, Anthony Hill as Winston Ndugu, and Kim Raver as Teddy Altman. Notably, Jake Borelli and Midori Francis are not part of this season.
Q. When to watch Grey’s Anatomy 22?
A. Grey’s Anatomy season 22 is out on ABC on October 9.
Q. How to watch Grey’s Anatomy’s new season in India?
A. Grey’s Anatomy season 22 is now streaming via JioHotstar and OTTplay Premium. The new episode will drop weekly on Friday.
Q. Is Ellen Pompeo returning in Grey’s Anatomy S22?
A. Yes, Ellen Pompeo is back as Dr. Meredith Grey in season 22.